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Thursday, April 3, 2008

THYROID FUNCTION TESTS

THYROID FUNCTION TESTS

These are laboratory tests that are performed to determine thyroid function.

PRECAUTIONS IN SPECIMEN COLLECTION & HANDLING

•RED TOP OR YELLOW TOP CAN BE USED
•AVOID USE OF LIPEMIC & HEMOLYZED SERUM
•NEWBORNS- FILTER PAPER BLOT CAN BE USED
•FASTING- NOT NEEDED
•SAMPLES CAN BE REFRIGERATED-24 HRS.
•FROZEN FOR 30 DAYS (AVOID REPEATED THAWING)

BLOOD TESTS:

•Thyroid-Stimulating Hormone (TSH)
This is a significant marker for hypothyroidism. an increase in its concentration indicates hypothyroidism and a decrease indicates hyperthyroidism
Thyroxine (T4) and Triiodothyronine (T3)
increased concentrations indicate hyperthyroidism
decreased concentrations indicate hypothroidism
•Thyroxine-Binding Globulin. (TBG)
this is the major binding protein of thyroid hormones
Other tests:
rT3, T3U, FTI, FT3, FT4

Stimulation Tests

•-TRH STIMULATION TEST
TRH IS INJECTED INTO THE PATIENT AND THE RESPONSE OF THE PITUITARY GLAND IS OBSERVED.
•TSH STIMULATION TEST

TSH IS GIVEN TO THE PATIENT AND THEN THE REPONSE OF THE THYROID GLAND IS MEASURED.

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